The arrest of former Pakistan Prime Minister Imran Khan and the call from his party for nationwide protests present another blow to the nuclear-armed country struggling with an economic crisis.
The South Asian nation of 220 million people is running out of dollars, inflation is running at over 36% and an expected IMF bailout has been delayed by months.
Industrial activity has virtually ground to a halt as the central bank has raised interest rates to a record 21% to battle inflation, worsening already-high unemployment and poverty.
Women and children have been killed in stampedes at food distribution centres as food inflation rises to an all-time high of 40%.
An IMF bailout programme, which expires in June, has been stalled since November. Foreign exchange reserves at $4.457 billion cover barely a month's worth of imports.
Debt relief from friendly countries such as China, Saudi Arabia and the United Arab Emirates has yet to materialise fully.
A revenue shortfall for the fiscal year through June is projected to overshoot targets substantially by most estimates, while the rupee remains weak.
Pakistan is in a constitutional standoff after Prime Minister Shehbaz Sharif's government in April rejected a Supreme Court order to hold local elections in Punjab province by the middle of May.
Non-compliance could result in court action against the government. The court has previously sacked two prime ministers.
Khan, arrested for alleged corruption and ousted as prime minister last year, had been ratcheting up pressure on the government through a sustained political campaign as he vied to return to power.
Authorities had made several attempts to arrest Khan since March, which had resulted in clashes between his supporters and law enforcement personnel.
Pakistan governments typically seek the backing of the powerful military, which has ruled the country for more than 30 of its 75 years. Military coups have followed political chaos three times.
Khan's arrest came a day after the military issued a rare statement denouncing him for making allegations against a serving officer.
The government says it plans a nationwide operation to root out Islamist militants in the face of recent attacks. The last such operation, in 2014, cost the country billions of dollars, killed hundreds and resulted in the displacement of about a million people.